Supply and return diffusers were adjusted about air flow and placed on both floors to make the actual airflow meets the requirement.
From the floor plan, I feel the layout can be improved.
The challenge that came first was that the height of ducts and diffusers. And the second challenge was the automatic connection in Revit sometimes gave confusion.
Based on the height I set for the diffusers and ducts, the HVAC system went under the structural system.